the effects of cyclooxygenase inhibitors on the brain inflammatory response following traumatic brain injury in rats
نویسندگان
چکیده
objective(s) cytokines such as il-1β are involved in inflammatory responses. this study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain il-10 and il-1β after traumatic brain injury (tbi) in male rats. materials and methods rats were assigned into 6 groups: intact, sham, tbi, and treated rats with vehicle, celecoxib or iboprophen. cytokine concentrations were quantified by elisa kits. results groups showed no significant difference in brain il-10 either after tbi induction or after treatment with ibuprofen or celecoxib. serum il-10 in vehicle or ibuprofen treated animals was lower than in sham groups (p< 0.01). brain il-1β decreased after treatment by ibuprofen or celecoxib (p< 0.001). there was no statistical difference in serum il-1β in tbi and intact. serum il-1β significantly decreased in rats that received celecoxib compared to tbi group (p< 0.01). conclusion based on our study il-1β can decrease through both cyclooxygenase 1 (cox-1) and cox-2 pathway but serum il-1β can decrease only by cox-2 pathway.
منابع مشابه
The Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats
Objective(s) Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations ...
متن کاملThe Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats
OBJECTIVES Cytokines such as IL-1β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1β after traumatic brain injury (TBI) in male rats. MATERIALS AND METHODS Rats were assigned into 6 groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations wer...
متن کاملThe effects of cyclooxygenase inhibitors on the gastric emptying and small intestine transit in the male rats following traumatic brain injury
Objective(s):This study was carried out to investigate the effects of COX-2 selective inhibitor (Celecoxib) or non-selective COX inhibitor (Ibuprofen) on gastrointestinal motility. Materials and Methods: The rats were randomly divided into five groups including: intact, sham, traumatic brain injury (TBI) group (intact rats under TBI), Celecoxib group (10 mg/kg), Ibuprofen group (10 mg/kg). Rats...
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متن کاملthe effects of cyclooxygenase inhibitors on the gastric emptying and small intestine transit in the male rats following traumatic brain injury
objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۵، شماره ۵، صفحات ۱۱۰۲-۱۱۰۵
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